July 28, 2024 6:45 PM PDT
Nicotinamide Mononucleotide, commonly known as NMN, has sparked quite a controversy with U.S. federal regulators in recent years. According to the Food and Drug Administration (FDA), NMN cannot lawfully be marketed as a dietary supplement in the U.S. However, plenty of manufacturers sell it, boasting its purported anti-aging properties.Get more news about
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NMN is a naturally-occurring molecule that classifies as a bioactive nucleotide. It’s a precursor of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme involved in multiple biological processes including aging and gene expression.
Nicotinamide converts to NMN, which then converts to NAD+ once it enters the body. An NAD+ deficiency can lead to potential health issues, including age-related metabolic disorders, mental disorders, and neurodegenerative diseases.
NMN appears in small amounts in various animal and plant food sources, including broccoli, avocados, and cucumbers. The body gets NMN from certain foods containing niacin, a B vitamin. Additional supplementation may be necessary if food alone can’t ultimately provide a person with sufficient amounts of NMN.
Aging can lead to declining NAD+ levels in various tissues throughout the body, including skeletal muscle. This decline is believed to contribute to age-related cellular dysfunction and impairments in tissue function.
Clinical studies on NMN in humans are limited, as most existing research relies on animal studies, so its efficacy has yet to be confirmed. At specific doses, NMN supplements may help improve insulin sensitivity and heart function and reduce tiredness with few side effects.
However, it’s a good idea to ask your doctor before trying it. If you’re interested in aging and longevity innovations, you may have heard of NMN. Scientists, such as Harvard University professor and longevity expert David Sinclair, are currently looking into its promising potential benefits for many different areas of health, including longevity, diabetes, liver conditions, brain health, heart health, exercise training, sleep.
Research on the effects of NMN supplements is still emerging, and more investigation is needed. All the cells in your body use NAD and therefore require NMN, its precursor, to function properly.
NAD helps cells regulate a number of essential functions that help keep your cells running smoothly, including energy metabolism, DNA repair, gene expression, cellular stress responses. It’s essential that your cells have plenty of NMN to produce enough NAD to support these functions.
Your NMN levels naturally decline over time, and, as a result, your levels of NAD decline, too. This may contribute to some of the health effects you might experience during aging.
For example, research has shown that people with different age-related conditions, including diabetes and liver diseases, may have lower levels of NMN and NAD. Test-tube and animal studies also suggest that NMN may play a role in other aspects of aging, including heart and brain health.
In conclusion, while NMN supplements show promise in various health-related areas, more research is needed to confirm their effectiveness and safety. Always consult with a healthcare professional before starting any new supplement regimen.