Softgels, also known as soft gelatin capsules, represent a specialized oral dosage form. These capsules consist of a gelatin-based shell that surrounds a liquid fill. In this article, we’ll explore the composition, production process, and advantages of softgels.Get more news about
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Composition of Softgels
Shell Material: The outer shell of softgels is primarily made of gelatin, water, an opacifier (to prevent light penetration), and a plasticizer (such as glycerin or sorbitol).
Liquid Fill: The inner content can vary and may include oils, vitamins, botanical extracts, or other active ingredients.
Production Process
The encapsulation of softgels involves a method called the Rotary Die Encapsulation process, which was invented by Robert Pauli Scherer. Here’s how it works:
Two flat ribbons of shell material are manufactured.
These ribbons are brought together on a twin set of rotating dies.
The dies cut out the ribbons into a two-dimensional shape and simultaneously form a seal around the outside.
A precise dose of fill material is delivered through a nozzle incorporated into a filling wedge.
The wedge injection causes the ribbons to expand into the die pockets, resulting in the three-dimensional finished product.
After encapsulation, the softgels are dried for a specific period, depending on the product.
Advantages of Softgels
Improved Bioavailability: Softgels enhance the absorption of lipophilic (fat-soluble) compounds due to their liquid form.
Easy Swallowing: Their smooth, gel-like texture makes them easier to swallow than some other dosage forms.
Taste Masking: Softgels can mask the taste of certain ingredients.
Stability: They protect sensitive ingredients from oxidation and light exposure.
Customization: Softgels allow for precise dosing and customization.
Conclusion
Softgels continue to be a popular choice for delivering various supplements and medications. Their versatility, ease of administration, and improved bioavailability make them a valuable option in the pharmaceutical and nutraceutical industries.